Glucosyl Naringin (GN) is an upcycled glycosylated citrus polyphenol developed by Nagase Viita (former Hayashibara). We have significantly increased the water solubility of Naringin through our glycosylation technology, enabling it to be effectively used in skin care products.
GN is scientifically proven to improve skin elasticity by promoting both the quality and quantity of elastin, making it a beneficial ingredient for anti-aging products. Our recent studies have shown that the effects of GN strengthen the skin’s barrier function and reduce UVB-induced stresses.
Strengthening the Skin Barrier Function
Maintaining a healthy skin barrier is essential to preventing skin irritation and dryness. Several components of the stratum corneum (SC) contribute to its barrier function. Filaggrin plays an important role by aggregating keratin within the SC to form keratin filaments. Meanwhile, the cornified envelope, a strong, membrane-like structure, protects the corneocytes. Both are essential to the overall structure of the SC.
In recent testing, the treatment by GN promoted the formation of cornified envelope and production of profilaggrin, precursor of filaggrin, which contributes to the strength and flexibility of SC. The results suggest that GN enhances skin barrier function and helps restore its natural strength.
Reducing UVB-induced stresses
UVB, a medium-wavelength ultraviolet radiation, is a known cause of sunburn. Its exposure induces an inflammatory response in the skin, leading to dark spots and wrinkles (Ichihashi et al., 2009). Our in vitro studies have shown that GN helps protect the skin from UVB-induced inflammation.
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Strengthen, rejuvenate, and protect your skin
GN strengthens your skin's resilience against stress and environmental disturbances while enhancing elasticity to rejuvenate your skin's natural beauty and promote overall well-being.
We will present GN’s new insights to improve circadian rhythm disruptions at the 2024 International Federation of Societies of Cosmetic Chemists (IFSCC) Congress in Brazil.
Reference: Ichihashi, M., Ando, H., Yoshida, M., Niki, Y., & Matsui, M. (2009). Photoaging of the skin. ANTI-AGING MEDICINE, 6(6), 46–59.
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