Exoceuticals landed at the Cosmoprof North America trade show in Las Vegas, July 23-25, 2024, heralding a new era of exosome-driven regenerative beauty that expands the skin's longevity.
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Exoceuticals landed at the Cosmoprof North America trade show in Las Vegas, July 23-25, 2024, heralding a new era of exosome-driven regenerative beauty that expands the skin's longevity.
What Are Exosomes?
Exosomes are particles that can range from ~30-200 nm in size, carrying genetic material, proteins and fats that, in the case of the skin, can signal other cells to instigate repair and rejuvenation activities.
The result is boosted skin health, a shift from superficial reparative concepts to a truly regenerative effect in anti-aging.
Notably, some professional beauty procedures can treat clients' skin using their own human exosomes. However, solutions on the consumer market tend to be plant-derived.
One 2024 study in the journal Cell Communication and Signaling concluded, "Anti-aging features of exosomes have been implicated in various in vitro and pre-clinical studies. Stem cell-derived exosomes can restore skin physiological function and regenerate or rejuvenate damaged skin tissue through various mechanisms such as decreased expression of matrix metalloproteinase (MMP), increased collagen and elastin production, and modulation of intracellular signaling pathways as well as intercellular communication."
Exoceuticals' Exosome Play
Exoceuticals' skin care features its eXo3 exosome technology, which delivers “proteins, growth factors, nucleic acids and MiRNAs to promote regeneration and healing,” per Exoceuticals.
Exoceutical’s skin care, featuring its eXo3 exosome technology, delivers “proteins, growth factors, nucleic acids and MiRNAs to promote regeneration and healing,” per the brand.Exoceuticals
Benefits include healing and regeneration following sun and other environmental exposures. And, because exosomes improve cellular communication, which is naturally diminished with age, they reduce the appearance of wrinkles, crow’s feet and dark spots, while boosting elasticity.
Co-founded by Robin L. Smith, MD, MBA, and Nicole Martin, MD (of Real Housewives of Miami fame), Exoceuticals’ exosome beauty includes the Exo H-Serum Hyaluronic Acid Treatment, Exo Face Perfection Moisturizer, Exo Sun After-Sun Treatment, Exo Plus Anti-Aging Cream, Exo C-Serum Vitamin C Treatment, Exo Body Advanced Body Lotion and Exo Men Hydrating Moisturizer.
These products reportedly significantly decrease the appearance of crow's feet after seven days while also boosting skin firmness.
Exoceuticals is hardly alone; exosomes have become a leading innovation pathway in beauty technologies.
- Recently, Vytrus Biotech leveraged its biotech expertise to develop intact plant exosomes for skin and hair care applications.
- And DSM-Firmenich has partnered with ExoLab Italia to bring plant-derived exosome technology to the global skin care market.
- In addition, Active Concepts has introduced its BioAuthentic Exosomes line for skin care, which utilizes green chemistry principles.
- Most recently, Korea’s J2KBio Co., Ltd. launched Lactosome 55 (INCI: Lactobacillus ferment (or Lactobacillus extracellular vesicles)), a skin care active made of exosomes obtained from Lactobacillus brevis J2K-55, which was first isolated from water radish kimchi from Jeju Island. The biofermented ingredient reportedly improves skin barrier function, supports wound healing and boosts skin brightening.
Among the brands leveraging exosomes are Beekman 1802, which features the Milk RX Advanced Better Aging Cream with two goat milk protein exosomes “that penetrate deeper into skin layers to fortify the skin barrier and promote skin longevity,” per the brand.Beekman 1802
The cream comprises Renexosome, Beekman 1802’s polypeptide complex pairing goat milk exosomes with a polypeptide, which is reportedly 4x more effective than retinol in terms of producing collagen in skin. The complex is also safe for sensitive skin because it “comes without the purging and irritation associated with traditional retinol and prescription tretinoin,” per the brand.
Renexosome’s goat milk exosomes are rich in keratin and immunoglobulins. These exosomes have an average size of 102.8 to 109.3 nanometers and a concentration of approximately 116 billion particles per milliliter.
The complex features LipoTrue’s Reneseed regenerative polypeptide, comprising a bioengineered form of transforming growth factor (TGFβ2) derived from vertically farmed N. benthamiana, the so-called “seed of youth.” The retinol-mimicking polypeptide reportedly accelerates collagen production by 31% without irritation, peeling or purging of the skin. The result, according to Beekman 1802, is an enhanced skin barrier for visibly firmer skin.
