ApiotiX Technologies Unveils Propolis-derived Retinol Alternative

Biotech expert ApiotiX Technologies has unveiled a standardized polyphenolic acid polymer extract (PAPE) derived from propolis that is clinically proven to offer the same benefits as retinol. It also demonstrates equal efficacy with the existing well-known alternative bakuchiol, and is described as the first natural retinol alternative with comparable purity.

"We genuinely believe that our research could stir up some interest in the industry, especially given the reactions we've been seeing," said Bozo Radic, Ph.D., COO of ApiotiX Technologies. "It all started with our work on wound healing, but we stumbled upon these surprising benefits for wrinkles, which was pretty amazing."

See related: Bee-based Beauty for Skin Health and Immunity

Clinical Anti-wrinkle Efficacy

In a clinical study, 40 female participants applied two products twice daily for 4 weeks (28 days): product A (1.5% PAPE), which improved wrinkles 25%; and product B (3% PAPE), which improved wrinkles by 34%. No adverse skin alterations were reported over 56 days.

Representative before/after effects of PAPE ingredient at Day 0 (left) and Day 28 (right)ApiotiX Technologies

Furthermore, participants reported high satisfaction, with 90% willing to continue use. Comprehensive dermatological assessments also confirmed excellent skin tolerance. The company recently published these results in the Journal of Cosmetic Dermatology.

Patented Standardized Propolis Extract

According to the patent disclosure, the PAPE is produced by extracting crude propolis with a solvent based on a mixture of PEG 200-600 (96.5-99.9% w/w) and lecithins (0.1-3.5% w/w). The resulting extract comprises standardized levels of p-coumaric acid, trans-ferulic acid, caffeic acid and 2-phenylethyl 3, 4-dihydroxy-trans-cinnamate CAPE.

The ingredient is named in the patent for uses ranging from pharmaceutical and veterinary, to cosmetic, agrochemical or functional food products. Applications beyond anti-aging and skin care include the treatment of inflammatory diseases, bacterial and fungal infections, viral, autoimmune and cancer diseases, and for the treatment of burns and wound healing.

Proprietary Extraction Process

ApiotiX Technologies uses a proprietary technology to develop its pharmaceutical-grade extracts. As the patent explains, considering propolis is a mixture of beeswax and a multitude of natural organic compounds, chemoselective extraction solvents are used to selectively extract certain predominant groups of organic compounds. When paired with suitable analytical methods, this can achieve a consistent and standardized propolis extract composition.

In vitro Anti-inflammation and Skin Remodeling

Underpinning the demonstrated clinical efficacy, the ingredient has demonstrated specific mechanisms of action in vitro. Radic explained: "Our evidence-based solutions with a defined mode of action make PAPE a promising addition to skin care. In vitro studies indicated that PAPE could modulate inflammation and tissue remodeling biomarkers, which is now evidently confirmed in clinical trial results. Together, these findings offer effects comparable to retinol but with an excellent safety profile."