Genemarkers, a trusted partner for applying genomic technologies to personal care product development, has launched a new testing service to evaluate how product formulations protect or repair skin in response to diesel particulate matter (DPM).
The service includes gene expression analysis using Genemarkers’ environmental stress panel. The panel is designed to help determine if pre-and/or post-treatment with a topical test material can prevent or repair damage induced by specific environmental stressors. Genemarkers can perform testing using in vitro or ex vivo skin tissues.
The environmental stress panel includes 107 genes that regulate skin functions, including:
- DNA repair;
- Epigenetics;
- Oxidative stress response;
- Survival/apoptosis/autophagy;
- Mitochondrial function and;
- Inflammation.
Genemarkers’ scientific team performed studies to validate the use of the environmental stress panel using a variety of stressors, including UV, blue light and most recently, DPM. Studies were performed using ex vivo human skin explants exposed to 30 minutes of DPM in a closed chamber. qPCR was performed 18 hours post-exposure. Results showed exposure to DPM increased the expression of oxidative stress genes, including NQO1 and CYP450 enzymes, inflammation, mitochondrial function and cell survival.
Genemarkers’ environmental stress gene expression panel enables clients to assess how their products repair damage caused by the skin's exposure to pollution and other environmental stressors.
Contact Alisha Morrison at [email protected] to learn more.
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